I think I finally found a consistent way to crash the game with the Insimenator: With an infant selected as the active sim and the DEST version of the Insimenator installed, click on a piece of terrain where you might use the "Spawn" function.
Kablooie! "The application has crashed and will now terminate."
Obviously, unless for some odd reason you really
want to crash the game, don't do this!
For what it's worth: I'm running all the expansion packs up through
Open For Business and all the stuff packs up through
Glamor Life Stuff, and nothing published after that.